Dermal-Epidermal Junction

Dermal-Epidermal Junction
Please see SuperSkin for the best anti-aging results


In skin, cohesion between the dermis and the epidermis is ensured by the dermal-epidermal junction which is also required for control of epidermal growth. The dermal-epidermal junction (DEJ) appears very early in development and has all the characteristics of the adult structure by the 9th week of gestation. Skin aging entails drastic changes in the extracellular dermal matrix (ECM) and dermal-epidermal junction (DEJ). These biological alterations are reflected in the clinical signs of aged skin.

The dermal-epidermal junction interlocks forming fingerlike projections called rete ridges. The cells of the epidermis receive their nutrients from the blood vessels in the dermis. The rete ridges increase the surface area of the epidermis that is exposed to these blood vessels and the needed nutrients. As a person ages the epidermal cells become thinner and less sticky. The thinner cells make the skin look noticeably thinner. The decreased stickiness of the cells decreases the effectiveness of the barrier function allowing moisture to be released instead of being kept in the skin. This causes dryness. The number of epidermal cells decreases by 10% per decade and they divide more slowly as we age making the skin less able to repair itself quickly.

The effects of aging on the dermal layer are significant. Not only does the dermal layer thin, but also less collagen is produced, and the elastin fibers that provide elasticity wear out. These changes in the scaffolding of the skin cause the skin to wrinkle and sag. Also, sebaceous glands get bigger but produce less sebum, and the number of sweat glands decreases. Both of these changes lead to skin dryness.

The rete-ridges of the dermal-epidermal junction flatten out, making the skin more fragile and making it easier for the skin to shear. This process also decreases the amount of nutrients available to the epidermis by decreasing the surface area in contact with the dermis, also interfering with the skin's normal repair process.

In the subcutaneous layer the fat cells get smaller with age. This leads to more noticeable wrinkles and sagging, as the fat cells cannot "fill in" the damage from the other layers.

High potency L-ascorbic acid Vitamin C is absorbed by the skin where it is efficiently converted by skin enzymes into vitamin C anti-oxidants. This valuable information regarding topical vitamin C was first introduced to the American Academy of Dermatology in 1995. It has been observed that over time vitamin C is photoprotective, stimulates collagen production and prevents UV immune-suppression. SS C Elixir will help to ward off both sun-induced and environmentally damaged skin by neutralizing free radicals. Research studies show that a topical vitamin C has useful properties. It is designed to go directly into the skin and provide pharmacological levels of protection. It becomes an inherent part of the skin, and is unaffected by bathing, exercise, clothing, or makeup. It is believed that it will be useful for treating sundamage and other inflammatory conditions, including acne, rosacea and erythema.


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